Melanom-Forschung

• Haake M, Haack B, Schäfer T, Harter PN, Mattavelli G, Eiring P, Vashist N, Wedekink F, Genssler S, Fischer B, Dahlhoff J, Mokhtari F, Kuzkina A, Welters MJP, Benz TM, Sorger L, Thiemann V, Almanzar G, Selle M, Thein K, Späth J, Gonzalez MC, Reitinger C, Ipsen-Escobedo A, Wistuba-Hamprecht K, Eichler K, Filipski K, Zeiner PS, Beschorner R, Goedemans R, Gogolla FH, Hackl H, Rooswinkel RW, Thiem A, Roche PR, Joshi H, Pühringer D, Wöckel A, Diessner JE, Rüdiger M, Leo E, Cheng PF, Levesque MP, Goebeler M, Sauer M, Nimmerjahn F, Schuberth-Wagner C, von Felten S, Mittelbronn M, Mehling M, Beilhack A, van der Burg SH, Riedel A, Weide B, Dummer R, Wischhusen J. Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment. Nat Commun. 2023 Jul 20;14(1):4253. doi: 10.1038/s41467-023-39817-3.

• Thiem A, Mashhadiakbar P, Cussigh C, Hassel JC, Grimmelmann I, Gutzmer R, Schlaak M, Heppt MV, Dücker P, Hüning S, Schulmeyer L, Schilling B, Haferkamp S, Ziemer M, Moritz RKC, Hagelstein V, Terheyden P, Posch C, Gaiser MR, Kropp P, Emmert S, Müller B, Tietze JK. Immune checkpoint inhibition and targeted therapy for melanoma: A patient-oriented cross-sectional comparative multicentre study. J Eur Acad Dermatol Venereol. 2023 May;37(5):884-893. doi: 10.1111/jdv.18778.

• Thiem A, Hesbacher S, Kneitz H, di Primio T, Heppt MV, Hermanns HM, Goebeler M, Meierjohann S, Houben R, Schrama D. IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression. J Exp Clin Cancer Res. 2019 Sep 11;38(1):397. doi: 10.1186/s13046-019-1403-9

   

Plasmamedizin

• Bekeschus S. Medical gas plasma technology: Roadmap on cancer treatment and immunotherapy. Redox Biol. 2023 Sep;65:102798. Epub 2023 Jun 27. PMID: 37556976; PMCID: PMC10433236. doi: 10.1016/j.redox.2023.102798

• Berner, J., Miebach, L., Kordt, M. et al. Chronic oxidative stress adaptation in head and neck cancer cells generates slow-cyclers with decreased tumour growth in vivo. Br J Cancer 129, 869–883 (2023). doi: 10.1038/s41416-023-02343-6

• Bernhardt T, Semmler ML, Schäfer M, Bekeschus S, Emmert S, Boeckmann L. Plasma Medicine: Applications of Cold Atmospheric Pressure Plasma in Dermatology. Oxid Med Cell Longev 2019 Sep 3;2019:3873928. doi:10.1155/2019/3873928

• Boeckmann L, Berner J, Kordt M, Lenz E, Schäfer M, Semmler ML, Frey A, Sagwal SK, Rebl H, Miebach L, Niessner F, Sawade M, Hein M, Ramer R, Grambow E, Seebauer C, von Woedtke T, Nebe B, Metelmann HR, Langer P, Hinz B, Vollmar B, Emmert S, Bekeschus S. Synergistic effect of cold gas plasma and experimental drug exposure exhibits skin cancer toxicity in vitro and in vivo. J Adv Res. 2024 Mar;57:181-196. Epub 2023 Jun 28. PMID: 37391038; PMCID: 10918357 doi: 10.1016/j.jare.2023.06.014

• Hofmeyer S, Weber F, Gerds S, Emmert S, Thiem A.  A Prospective Randomized Controlled Pilot Study to Assess the Response and Tolerability of Cold Atmospheric Plasma for Rosacea. Skin Pharmacol Physiol. 2023;36(4):205-213. doi: 10.1159/000533190.

• Meinke MC*, Hasse S*, Schleusener J, Hahn V, Gerling T, Rasnani KH, Bernhardt T, Ficht P-K, Staffeld A, Bekeschus S, Lademann J, Emmert S, Lohan SB*, Boeckmann L*. Radical formation in skin and preclinical characterization of a novel medical plasma device for dermatology. Free Radical Biology and Medicine 2024; doi: 10.1016/j.freeradbiomed.2024.11.026

• Miebach L, Melo-Zainzinger G, Freund E, Clemen R, Cecchini AL, Bekeschus S, Medical Gas Plasma Technology Combines with Antimelanoma Therapies and Promotes Immune-Checkpoint Therapy Responses. Adv. Sci. 2023, 10, 2303183. doi:10.1002/advs.202303183

• van Welzen A, Hoch M, Wahl P, Weber F, Rode S, Tietze JK, Boeckmann L, Emmert S, Thiem A. The Response and Tolerability of a Novel Cold Atmospheric Plasma Wound Dressing for the Healing of Split Skin Graft Donor Sites: A Controlled Pilot Study. Skin Pharmacol Physiol. 2021;34(6):328-336. doi: 10.1159/000517524

   

Psoriasis / chronisch-entzündliche Hauterkrankungen

• Heidbrede T, Mevius A, Kessel S, Wilke T, Maywald U, Thiem A. Real-world systemic treatment of patients with psoriasis: A retrospective study based on German claims data. J Dtsch Dermatol Ges. 2023 Jun;21(6):611-619. doi: 10.1111/ddg.15030.

Seltene genetisch bedingte Erkrankungen 

• Martens MC, Edelkamp J, Seebode C, Schäfer M, Stählke S, Krohn S, Jung O, Murua Escobar H, Emmert S, Boeckmann L. Generation and characterization of a CRISPR/Cas9-mediated SNAP29 knockout in human fibroblasts. Int. J. Mol. Sci. 2021 May:(22)5293 doi: 10.3390/ijms22105293